Metagenomic Next-Generation Sequencing of Plasma for Diagnosis of COVID-19-Associated Pulmonary Aspergillosis
Journal of Clinical Microbiology (February 2023)
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Clinical EvidenceClinical Data
Some of the publications and abstracts listed on this page may reference the Karius Spectrum test under it's former name Karius Test. This product was rebranded to Karius Spectrum as of March 17, 2025.
Key Publications
The effect of a plasma next-generation sequencing test on antimicrobial management in immunocompetent and immunocompromised patients - A single-center retrospective study
Cambridge University Press (February 2023)
Metagenomics in infectious disease diagnostics: Toward best-use practices to optimize actionable results
Transplant Infectious Disease (December 2022)
Cell-free next-generation sequencing impacts diagnosis and antimicrobial therapy in immunocompromised hosts: A retrospective study
Transplant Infectious Disease (January 2023)
Budget Impact of Microbial Cell-Free DNA Testing Using the Karius Test as an Alternative to Invasive Procedures in Immunocompromised Patients with Suspected Invasive Fungal Infections
Applied Health Economics and Health Policy (2020)
Prosthetic Valve Infective Endocarditis Secondary to Neisseria elongata
Cureus (2023)
Disseminated blastomycosis with an intracranial fungoma in an immunocompetent patient: Illustrative case
Journal of Neurosurgery (January 2023)
Karius with a Q: role for microbial cell-free DNA next generation sequencing in diagnosis of acute Q fever
Open Forum Infectious Diseases (2022)
An 11-Year-old Boy With Fever and Rash
The Pediatric Infectious Disease Journal (2022)
Hiding in Plain Sight - A 64-year-old man presented to a rheumatology clinic with migratory polyarthralgias. He noted fatigue but no rash, dyspnea, chest pain, dysuria, fever, chills, or gastrointestinal symptoms.
New England Journal of Medicine (2022)
Clinical Impact of Non-invasive Plasma Microbial Cell-free Deoxyribonucleic Acid Sequencing for the Diagnosis and Management of Pneumocystis jirovecii Pneumonia: A Single-Center Retrospective Study
Open Forum Infectious Diseases (2022)
Could cell-free DNA and host biomarkers assist in antimicrobial stewardship with organ transplant recipients?
Transplant Infectious Disease (2022)
Plasma Microbial Cell-Free DNA (CF-DNA) Next- Generation Sequencing in Diagnosing Intracranial Abscesses: Pathophysiology and a Scoping Review of the Literature
(August 2022)
Noninvasive monitoring of infection and rejection after lung transplantation
PNAS (October 2015)
The Next Big Thing? Next-Generation Sequencing of Microbial Cell-Free DNA Using the Karius Test
Clinical Microbiology Newsletter (May 2021)